Do statins decrease the production of ketones?

Statins are a class of drugs that target the body’s production of cholesterol in the liver, but they have other effects as well. One of these side effects is a reduction in the body’s level of inflammation, which may be beneficial. There are no known problems associated with combining statin use with a well-formulated ketogenic diet. In fact, Jeff Volek’s team did a study in which they recruited people who were already taking a statin and then put them on a ketogenic diet for 6 weeks. As a group, they lost weight and had improved blood lipids (e.g., reduced triglycerides, reduced small LDL particles). But to the point of this question, their blood ketone levels went up into the nutritional ketosis range as expected.

  1. Dietary carbohydrate restriction improves insulin sensitivity, blood pressure, microvascular function, and cellular adhesion markers in individuals taking statins. Ballard KD, Quann EE, Kupchak BR, Volk BM, Kawiecki DM, Fernandez ML, Seip RL, Maresh CM, Kraemer WJ, Volek JS.Nutr Res. 2013 Nov;33(11):905-12.